Just to be sure I reinstalled the MyODBC drivers from serverlogistics.
I run iODBC and install the driver, just using the out of the box odbc.ini file, and the libmyodbc3.bundle symlink. However, when I add a DSN, and select the driver, I get the following: "An error occurred when trying to add the DSN: Could not load the driver or translator setup library".
Otherwise, my MySQL installation is working fine. I just can't get ODBC working to save my life.